Evolution, genomic analysis, and reconstruction of isobutanol tolerance in Escherichia coli

Escherichia coli has been engineered to produce isobutanol, with titers reaching greater than the toxicity level. However, the specific effects of isobutanol on the cell have never been fully understood. Here, we aim to identify genotype–phenotype relationships in isobutanol response. An isobutanol‐...

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Bibliographic Details
Main Authors: Shota Atsumi, Tung‐Yun Wu, Iara M P Machado, Wei‐Chih Huang, Pao‐Yang Chen, Matteo Pellegrini, James C Liao
Format: Article
Language:English
Published: Springer Nature 2010-01-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2010.98