Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

The structure-function and optimization studies of NaV-inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing NaV1.7. With several NaV subtypes emerging as potential therapeutic targets, structure-function analysis of NaV-inhibiting spider toxins at such...

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Bibliographic Details
Main Authors: Yashad Dongol, David T. Wilson, Norelle L. Daly, Fernanda C. Cardoso, Richard J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
ICK toxins
rational design
spider toxin
Ssp1a
structure-function
voltage-gated sodium channels
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1277143/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1277143/full

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