HSP90 Inhibitors Modulate SARS-CoV-2 Spike Protein Subunit 1-Induced Human Pulmonary Microvascular Endothelial Activation and Barrier Dysfunction

HSP90 Inhibitors Modulate SARS-CoV-2 Spike Protein Subunit 1-Induced Human Pulmonary Microvascular Endothelial Activation and Barrier Dysfunction

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 5 million deaths worldwide. Multiple reports indicate that the endothelium is involved during SARS-Cov-2-related disease (COVID-19). Indeed, COVID-19 patients display increased thrombophilia with arterial and venous em...

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Bibliographic Details
Main Authors: Ruben Manuel Luciano Colunga Biancatelli, Pavel A. Solopov, Betsy Gregory, Yara Khodour, John D. Catravas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Physiology
Subjects:
SARS-CoV-2
spike protein
endothelial dysfunction
heat shock proteins
HSP90 inhibitors
AUY-922
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.812199/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.812199/full

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