Local production of reactive oxygen species drives vincristine-induced axon degeneration
Abstract Neurological side effects arising from chemotherapy, such as severe pain and cognitive impairment, are a major concern for cancer patients. These major side effects can lead to reduction or termination of chemotherapy medication in patients, negatively impacting their prognoses. With cancer...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-12-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-06227-8 |
| _version_ | 1797397788144697344 |
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| author | Jorge Gomez-Deza Anastasia L. Slavutsky Matthew Nebiyou Claire E. Le Pichon |
| author_facet | Jorge Gomez-Deza Anastasia L. Slavutsky Matthew Nebiyou Claire E. Le Pichon |
| author_sort | Jorge Gomez-Deza |
| collection | DOAJ |
| description | Abstract Neurological side effects arising from chemotherapy, such as severe pain and cognitive impairment, are a major concern for cancer patients. These major side effects can lead to reduction or termination of chemotherapy medication in patients, negatively impacting their prognoses. With cancer survival rates improving dramatically, addressing side effects of cancer treatment has become pressing. Here, we use iPSC-derived human neurons to investigate the molecular mechanisms that lead to neurotoxicity induced by vincristine, a common chemotherapeutic used to treat solid tumors. Our results uncover a novel mechanism by which vincristine causes a local increase in mitochondrial proteins that produce reactive oxygen species (ROS) in the axon. Vincristine triggers a cascade of axon pathology, causing mitochondrial dysfunction that leads to elevated axonal ROS levels and SARM1-dependent axon degeneration. Importantly, we show that the neurotoxic effect of increased axonal ROS can be mitigated by the small molecule mitochondrial division inhibitor 1 (mdivi-1) and antioxidants glutathione and mitoquinone, identifying a novel therapeutic avenue to treat the neurological effects of chemotherapy. |
| first_indexed | 2024-03-09T01:15:13Z |
| format | Article |
| id | doaj.art-fd8aa3cb73e4442bad6f1a9a1c87bf3a |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-09T01:15:13Z |
| publishDate | 2023-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-fd8aa3cb73e4442bad6f1a9a1c87bf3a2023-12-10T12:33:36ZengNature Publishing GroupCell Death and Disease2041-48892023-12-01141211310.1038/s41419-023-06227-8Local production of reactive oxygen species drives vincristine-induced axon degenerationJorge Gomez-Deza0Anastasia L. Slavutsky1Matthew Nebiyou2Claire E. Le Pichon3Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthAbstract Neurological side effects arising from chemotherapy, such as severe pain and cognitive impairment, are a major concern for cancer patients. These major side effects can lead to reduction or termination of chemotherapy medication in patients, negatively impacting their prognoses. With cancer survival rates improving dramatically, addressing side effects of cancer treatment has become pressing. Here, we use iPSC-derived human neurons to investigate the molecular mechanisms that lead to neurotoxicity induced by vincristine, a common chemotherapeutic used to treat solid tumors. Our results uncover a novel mechanism by which vincristine causes a local increase in mitochondrial proteins that produce reactive oxygen species (ROS) in the axon. Vincristine triggers a cascade of axon pathology, causing mitochondrial dysfunction that leads to elevated axonal ROS levels and SARM1-dependent axon degeneration. Importantly, we show that the neurotoxic effect of increased axonal ROS can be mitigated by the small molecule mitochondrial division inhibitor 1 (mdivi-1) and antioxidants glutathione and mitoquinone, identifying a novel therapeutic avenue to treat the neurological effects of chemotherapy.https://doi.org/10.1038/s41419-023-06227-8 |
| spellingShingle | Jorge Gomez-Deza Anastasia L. Slavutsky Matthew Nebiyou Claire E. Le Pichon Local production of reactive oxygen species drives vincristine-induced axon degeneration Cell Death and Disease |
| title | Local production of reactive oxygen species drives vincristine-induced axon degeneration |
| title_full | Local production of reactive oxygen species drives vincristine-induced axon degeneration |
| title_fullStr | Local production of reactive oxygen species drives vincristine-induced axon degeneration |
| title_full_unstemmed | Local production of reactive oxygen species drives vincristine-induced axon degeneration |
| title_short | Local production of reactive oxygen species drives vincristine-induced axon degeneration |
| title_sort | local production of reactive oxygen species drives vincristine induced axon degeneration |
| url | https://doi.org/10.1038/s41419-023-06227-8 |
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