A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses

A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses

Acute pancreatitis (AP) is a devastating disease characterized by an inflammatory disorder of the pancreas. P-selectin glycoprotein ligand-1 (PSGL-1) plays a crucial role in the initial steps of the adhesive at process to inflammatory sites, blockade of PSGL-1 might confer potent anti-inflammatory e...

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Bibliographic Details
Main Authors: Yuhan Li, Xiangqing Ding, Xianxian Wu, Longfei Ding, Yuhui Yang, Xiaoliang Jiang, Xing Liu, Xu Zhang, Jianrong Su, Jianqing Xu, Zhiwei Yang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Acute pancreatitis
PSGL-1
Non-human primate
Monoclonal antibody
Therapeutic antibody RH001-6
Adhesion of leukocytes to endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002903

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http://www.sciencedirect.com/science/article/pii/S2211383523002903

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