Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions

Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions

Focal adhesion kinase (FAK) is a cytoplasmic non-receptor protein tyrosine kinase that is overexpressed and activated in many human cancers. FAK transmits signals to a wide range of targets through both kinase-dependant and independent mechanism thereby playing essential roles in cell survival, prol...

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Bibliographic Details
Main Authors: Antoine Mousson, Emilie Sick, Philippe Carl, Denis Dujardin, Jan De Mey, Philippe Rondé
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Cancers
Subjects:
FAK
cancer signalling
PPI inhibitor
FAK inhibitor
Online Access:http://www.mdpi.com/2072-6694/10/9/278

Internet

http://www.mdpi.com/2072-6694/10/9/278

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