Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine

Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine

Abstract Background Cancer is a somatic evolutionary disease and adenocarcinomas of the stomach and gastroesophageal junction (GC) may serve as a two-dimensional model of cancer expansion, in which tumor subclones are not evenly mixed during tumor progression but rather spatially separated and diver...

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Bibliographic Details
Main Authors: Christoph Röcken, Anu Amallraja, Christine Halske, Luka Opasic, Arne Traulsen, Hans-Michael Behrens, Sandra Krüger, Anne Liu, Jochen Haag, Jan-Hendrik Egberts, Philip Rosenstiel, Tobias Meißner
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Genome Medicine
Subjects:
Gastric cancer
Intratumoral heterogeneity
Evolution
SMAD4
TP53
Online Access:https://doi.org/10.1186/s13073-021-00975-y

Internet

https://doi.org/10.1186/s13073-021-00975-y

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