The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression

The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression

Enhanced nucleoside metabolism is one of the hallmarks of cancer. Uridine-cytidine kinase 2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to phosphorylate uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. Recent studies...

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Bibliographic Details
Main Authors: Yi Fu, Xin-dong Wei, Luoting Guo, Kai Wu, Jiamei Le, Yujie Ma, Xiaoni Kong, Ying Tong, Hailong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
UCK2
chemotherapy
pyrimidine salvage synthesis
tumor development and progression
non-metabolic role of UCK2
oncogene
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.904887/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.904887/full

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