Peroxisome proliferator-activated receptor α is required for feedback regulation of highly unsaturated fatty acid synthesis1

Peroxisome proliferator-activated receptor α is required for feedback regulation of highly unsaturated fatty acid synthesis1

Δ6 desaturase (D6D), the rate-limiting enzyme for highly unsaturated fatty acid (HUFA) synthesis, is induced by essential fatty acid-deficient diets. Sterol regulatory element-binding protein-1c (SREBP-1c) in part mediates this induction. Paradoxically, D6D is also induced by ligands of peroxisome p...

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Bibliographic Details
Main Authors: Yue Li, Takayuki Y. Nara, Manabu T. Nakamura
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Journal of Lipid Research
Subjects:
Δ6 desaturase
arachidonic acid
docosahexaenoic acid
essential fat deficiency
liver
peroxisome proliferator-activated receptor α-null mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328819

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http://www.sciencedirect.com/science/article/pii/S0022227520328819

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