Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Abstract Background Aberrant expressions of desmoglein 2 (Dsg2) and desmocollin 2(Dsc2), the two most widely distributed desmosomal cadherins, have been found to play various roles in cancer in a context-dependent manner. Their specific roles on breast cancer (BC) and the potential mechanisms remain...

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Autors principals: Ji-Yuan Han, Na Che, Jing Mo, Dan-Fang Zhang, Xiao-Hui Liang, Xue-Yi Dong, Xiu-Lan Zhao, Bao-Cun Sun
Format: Article
Idioma:English
Publicat: BMC 2024-04-01
Col·lecció:BMC Cancer
Matèries:
Desmoglein 2 (Dsg2)
Desmocollin 2 (Dsc2)
Breast cancer
ERK
AKT
β-catenin
Accés en línia:https://doi.org/10.1186/s12885-024-12229-2

Internet

https://doi.org/10.1186/s12885-024-12229-2

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