In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons

In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons

Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture Aβ and its precursor proteins (i.e., APP and...

Full description

Bibliographic Details
Main Authors: Alec K. McKendell, Mei C. Q. Houser, Shane P. C. Mitchell, Michael S. Wolfe, Oksana Berezovska, Masato Maesako
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biosensors
Subjects:
Alzheimer’s disease
fluorescence resonance energy transfer (FRET)
γ-secretase
glycoconjugates
intracellular amyloid-beta (Aβ)
lysosomes
Online Access:https://www.mdpi.com/2079-6374/12/8/663

Internet

https://www.mdpi.com/2079-6374/12/8/663

Similar Items