Liver-targeted nanoparticles delivering nitric oxide reduce portal hypertension in cirrhotic rats

Liver-targeted nanoparticles delivering nitric oxide reduce portal hypertension in cirrhotic rats

Nitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by poly(beta-amino ester) nanoparticles (pBAE NPs) in experimental cirrhosis. Retinol-functionalized NO donor...

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Bibliographic Details
Main Authors: Meritxell Perramón, María Navalón-López, Guillermo Fernández-Varo, Alazne Moreno-Lanceta, Rocío García-Pérez, Joana Faneca, Mario López-Moya, Cristina Fornaguera, Judith García-Villoria, Manuel Morales-Ruiz, Pedro Melgar-Lesmes, Salvador Borrós, Wladimiro Jiménez
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Nanomedicine
Liver cirrhosis
Portal pressure
Inflammation
Nitric oxide donor
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000246

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http://www.sciencedirect.com/science/article/pii/S0753332224000246

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