Circulating messenger RNA variants as a potential biomarker for surveillance of hepatocellular carcinoma

Circulating messenger RNA variants as a potential biomarker for surveillance of hepatocellular carcinoma

Background and rationaleLiver derived messenger ribonucleic acid (mRNA) transcripts were reported to be elevated in the circulation of hepatocellular carcinoma (HCC) patients. We now report the detection of high-risk mRNA variants exclusively in the circulation of HCC patients. Numerous genomic alle...

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Bibliographic Details
Main Authors: Timothy Block, Daniel Zezulinski, David E. Kaplan, Jingqiao Lu, Samantha Zanine, Tingting Zhan, Cataldo Doria, Aejaz Sayeed
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
circulating mRNA variants
hepatocellular carcinoma
liver cirrhosis
extracellular vesicles
HCC surveillance and early detection
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.963641/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.963641/full

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