A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

Conventional drug design embraces the "one gene, one drug, one disease" philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs that act via polypharmacological mechanisms can produce compounds that ex...

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Bibliographic Details
Main Authors: Jacob D Durrant, Rommie E Amaro, Lei Xie, Michael D Urbaniak, Michael A J Ferguson, Antti Haapalainen, Zhijun Chen, Anne Marie Di Guilmi, Frank Wunder, Philip E Bourne, J Andrew McCammon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2799658?pdf=render

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http://europepmc.org/articles/PMC2799658?pdf=render

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