Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations

Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations

Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of proarrhythmic effects of herbal products. Here, we...

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Bibliographic Details
Main Authors: Bozhidar Baltov, Stanislav Beyl, Igor Baburin, Jakob Reinhardt, Phillip Szkokan, Aleksandra Garifulina, Eugen Timin, Udo Kraushaar, Olivier Potterat, Matthias Hamburger, Philipp Kügler, Steffen Hering
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Toxicology Reports
Subjects:
Evodia rutaecarpa
Cardiac safety
HERG
TdP
HiPSC-CMs
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750023000471

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http://www.sciencedirect.com/science/article/pii/S2214750023000471

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