Metoprolol disrupts inflammatory response of human cardiomyocytes via β-arrestin2 biased agonism and NF-κB signaling modulation

Metoprolol disrupts inflammatory response of human cardiomyocytes via β-arrestin2 biased agonism and NF-κB signaling modulation

Aims: Recent evidence supports non-class cardioprotective effects of metoprolol against neutrophil-mediated ischemia-reperfusion injury during exacerbated inflammation. Whether metoprolol exerts direct anti-inflammatory effect on cardiomyocytes is unknown. Accordingly, we aimed to investigate the di...

Full description

Bibliographic Details
Main Authors: Fabrizio Ricci, Andrea Di Credico, Giulia Gaggi, Giovanni Iannetti, Barbara Ghinassi, Sabina Gallina, Brian Olshansky, Angela Di Baldassarre
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Metoprolol
Biased agonism
β-arrestin
Cardiomyocyte
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016025

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223016025

Similar Items