TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells

The discovery of the Ten-Eleven Translocation (TET) protein family was initiated by the identification of the MLL partner TET1, and of mutations in the TET2 gene in hematological malignancies including myeloproliferative neoplasms (MPN). TET1, 2 and 3 proteins hydroxylate 5-methylcytosine (5-mC) int...

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Bibliographic Details
Main Authors: Lise Secardin, Cintia Elisabeth Gomez Limia, Antonio di Stefano, Martin Hernan Bonamino, Joseph Saliba, Keisuke Kataoka, Stevens K. Rehen, Hana Raslova, Caroline Marty, Seishi Ogawa, William Vainchenker, Barbara da Costa Reis Monte-Mor, Isabelle Plo
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120300593

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http://www.sciencedirect.com/science/article/pii/S1873506120300593

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