Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance

Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance

The emergence and spread of the mobile colistin-resistance gene, mcr-1, and its variants pose a challenge to the use of colistin, a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant (XDR) Gram-negative pathogens. Antibiotic adjuvants are a promising strategy...

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Bibliographic Details
Main Authors: Huangwei Song, Xueyang Wang, Muchen Zhang, Zhiyu Zou, Siyuan Yang, Tian Yi, Jianfeng Wang, Dejun Liu, Yingbo Shen, Chongshan Dai, Zhihai Liu, Timothy R. Walsh, Jianzhong Shen, Congming Wu, Yang Wang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Engineering
Subjects:
Chelerythrine
Antibiotic adjuvant
Conjugation inhibitor
Colistin
mcr-1
Dual effects
Online Access:http://www.sciencedirect.com/science/article/pii/S2095809923003740

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http://www.sciencedirect.com/science/article/pii/S2095809923003740

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