Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against <i>β</i>-ketoacyl-[acyl carrier protein] synthase II (FabF) and <i>β</i>-ketoacyl-[acyl carrier protein] synthase I (FabB), while the p...

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Bibliographic Details
Main Authors: Youchao Deng, Yuling Li, Zhongqing Wen, Claudia H. Ruiz, Xiang Weng, Michael D. Cameron, Yanwen Duan, Yong Huang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antibiotics
Subjects:
platensimycin
<i>Staphylococcus aureus</i>
antibiotic
FabF
FabB
C–C cross-coupling reactions
Online Access:https://www.mdpi.com/2079-6382/11/4/425

Internet

https://www.mdpi.com/2079-6382/11/4/425

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