Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity
Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against <i>β</i>-ketoacyl-[acyl carrier protein] synthase II (FabF) and <i>β</i>-ketoacyl-[acyl carrier protein] synthase I (FabB), while the p...
Main Authors: | Youchao Deng, Yuling Li, Zhongqing Wen, Claudia H. Ruiz, Xiang Weng, Michael D. Cameron, Yanwen Duan, Yong Huang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-03-01
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Series: | Antibiotics |
Subjects: | |
Online Access: | https://www.mdpi.com/2079-6382/11/4/425 |
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