Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy

Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy

Abstract Objective The drug‐refractory epilepsy (DRE) in children is commonly observed but the underlying mechanisms remain elusive. We examined whether fatty acids (FAs) and lipids are potentially associated with the pharmacoresistance to valproic acid (VPA) therapy. Methods This single‐center, ret...

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Bibliographic Details
Main Authors: Hong‐Li Guo, Wei‐Jun Wang, Na Dong, Yue‐Tao Zhao, Hao‐Ran Dai, Ya‐Hui Hu, Yuan‐Yuan Zhang, Jie Wang, Jin‐Chun Qiu, Xiao‐Peng Lu, Feng Chen
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Epilepsia Open
Subjects:
children
drug‐refractory epilepsy
fatty acids
lipidomics
metabolomics
Online Access:https://doi.org/10.1002/epi4.12712

Internet

https://doi.org/10.1002/epi4.12712

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