Metabolic Responses to Polymyxin Treatment in <italic toggle="yes">Acinetobacter baumannii</italic> ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling

ABSTRACT Multidrug-resistant (MDR) Acinetobacter baumannii has emerged as a very problematic pathogen over the past decades, with a high incidence in nosocomial infections. Discovered in the late 1940s but abandoned in the 1970s, polymyxins (i.e., polymyxin B and colistin) have been revived as the l...

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Bibliographic Details
Main Authors: Yan Zhu, Jinxin Zhao, Mohd Hafidz Mahamad Maifiah, Tony Velkov, Falk Schreiber, Jian Li
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mSystems
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00157-18