Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation

Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation

IntroductionNeurotransmitter release at presynaptic active zones (AZs) requires concerted protein interactions within a dense 3D nano-hemisphere. Among the complex protein meshwork the (M)unc-13 family member Unc-13 of Drosophila melanogaster is essential for docking of synaptic vesicles and transmi...

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Bibliographic Details
Main Authors: Sven Dannhäuser, Achmed Mrestani, Florian Gundelach, Martin Pauli, Fabian Komma, Philip Kollmannsberger, Markus Sauer, Manfred Heckmann, Mila M. Paul
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
active zone
Unc-13
MiMIC
presynaptic homeostasis
nanoarchitecture
localization microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1074304/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.1074304/full

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