A generic liquid chromatography-mass spectrometry method for monitoring bis(pinacolato)diboron mutagenic impurity in pharmaceutical compounds

A generic liquid chromatography-mass spectrometry method for monitoring bis(pinacolato)diboron mutagenic impurity in pharmaceutical compounds

Bis(pinacolato)diboron (B2Pin2) is a common reagent used to prepare pinacolboronate esters for Suzuki-Miyaura coupling reactions in pharmaceutical syntheses. As a known mutagenic impurity, it is challenging to develop analytical methods for the determination of B2Pin2 due to its low control limit, h...

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Bibliographic Details
Main Authors: Ziqing Lin, Hua-Chia Tai, Emanuele Petruzzella, Feili Tang, Yun K. Ye, James Chadwick, Wei Ding, Brian Lingfeng He, Scott A. Miller
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Journal of Chromatography Open
Subjects:
B2Pin2
Mutagenic impurity
LC-MS
Gas-phase ion manipulation
Solution stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2772391721000098

Internet

http://www.sciencedirect.com/science/article/pii/S2772391721000098

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