A generic liquid chromatography-mass spectrometry method for monitoring bis(pinacolato)diboron mutagenic impurity in pharmaceutical compounds

A generic liquid chromatography-mass spectrometry method for monitoring bis(pinacolato)diboron mutagenic impurity in pharmaceutical compounds

Bis(pinacolato)diboron (B2Pin2) is a common reagent used to prepare pinacolboronate esters for Suzuki-Miyaura coupling reactions in pharmaceutical syntheses. As a known mutagenic impurity, it is challenging to develop analytical methods for the determination of B2Pin2 due to its low control limit, h...

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Bibliographic Details
Main Authors:	Ziqing Lin, Hua-Chia Tai, Emanuele Petruzzella, Feili Tang, Yun K. Ye, James Chadwick, Wei Ding, Brian Lingfeng He, Scott A. Miller
Format:	Article
Language:	English
Published:	Elsevier 2021-11-01
Series:	Journal of Chromatography Open
Subjects:	B2Pin2 Mutagenic impurity LC-MS Gas-phase ion manipulation Solution stability
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772391721000098

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