Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion

Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion

Abstract Cancer‐associated fibroblasts (CAFs) as a predominant cell component in the tumour microenvironment (TME) play an essential role in tumour progression. Our earlier studies revealed oxidized ATM activation in breast CAFs, which is independent of DNA double‐strand breaks (DSBs). Oxidized ATM...

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Bibliographic Details
Main Authors: Lei Xi, Meixi Peng, Shuiqing Liu, Yongcan Liu, Xueying Wan, Yixuan Hou, Yilu Qin, Liping Yang, Shanchun Chen, Huan Zeng, Yong Teng, Xiaojiang Cui, Manran Liu
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Journal of Extracellular Vesicles
Subjects:
autophagy
cancer‐associated fibroblasts
exosomes
invasion
oxidized ATM
Online Access:https://doi.org/10.1002/jev2.12146

Internet

https://doi.org/10.1002/jev2.12146

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