Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2α) inhibitor, retards metastasis via disrupting HHEX/CCL20 signaling cascade involved in tumor cell extravasation across endothelial barrier

Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2α) inhibitor, retards metastasis via disrupting HHEX/CCL20 signaling cascade involved in tumor cell extravasation across endothelial barrier

Tumor cell extravasation across endothelial barrier has been recognized as a pivotal event in orchestrating metastasis formation. This event is initiated by the interactions of extravasating tumor cells with endothelial cells (ECs). Therefore, targeting the crosstalk between tumor cells and ECs migh...

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Bibliographic Details
Main Authors: Weiwei Zheng, Peiliang Shen, Chang Yu, Yu Tang, Cheng Qian, Chunmei Yang, Mingliang Gao, Yuanyuan Wu, Suyun Yu, Weiwei Tang, Guiping Wan, Aiyun Wang, Yin Lu, Yang Zhao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Pharmacological Research
Subjects:
Ginsenoside Rh1
Tumor cell extravasation
CCL20
Endothelial permeability
HHEX
CK2α
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003420

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http://www.sciencedirect.com/science/article/pii/S1043661823003420

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