Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract

Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract

IntroductionCataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%. To date, 55 loci for cataract have been identified by genome-wide association st...

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Manylion Llyfryddiaeth
Prif Awduron: Hélène Choquet, Matthieu Duot, Victor A. Herrera, Sanjaya K. Shrestha, Travis J. Meyers, Thomas J. Hoffmann, Poorab K. Sangani, Salil A. Lachke
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Frontiers Media S.A. 2024-04-01
Cyfres:Frontiers in Ophthalmology
Pynciau:
genetics
TWAS - transcriptome-wide association study
gene expression
lens tissue
cataract
multi-tissue analysis
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fopht.2024.1362350/full

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https://www.frontiersin.org/articles/10.3389/fopht.2024.1362350/full

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