Exploring bi-carbazole-linked triazoles as inhibitors of prolyl endo peptidase via integrated in vitro and in silico study

Exploring bi-carbazole-linked triazoles as inhibitors of prolyl endo peptidase via integrated in vitro and in silico study

Abstract A serine protease called prolyl endopeptidase (PEP) hydrolyses the peptide bonds on the carboxy side of the proline ring. The excessive PEP expression in brain results in neurodegenerative illnesses like dementia, Alzheimer’s disease, and Parkinson's disease. Results of the prior studi...

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Bibliographic Details
Main Authors: Saeed Ullah, Farheen Mansoor, Salman Ali Khan, Uzma Jabeen, Amany I. Almars, Hailah M. Almohaimeed, Ahmed M. Basri, Fahad M. Alshabrmi
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Bi-carbazole-linked triazoles
In vitro
Molecular docking simulation
Prolyl endo peptidase inhibitory activity
Kinetic studies
Online Access:https://doi.org/10.1038/s41598-024-58428-6

Internet

https://doi.org/10.1038/s41598-024-58428-6

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