CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines

Abstract Nanoparticle vaccines based on H. pylori ferritin are increasingly used as a vaccine platform for many pathogens, including RSV, influenza, and SARS-CoV-2. They have been found to elicit enhanced, long-lived B cell responses. The basis for improved efficacy of ferritin nanoparticle vaccines...

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Bibliographic Details
Main Authors: Sean A. Nelson, Katherine A. Richards, Maryah A. Glover, Francisco A. Chaves, Michelle C. Crank, Barney S. Graham, Masaru Kanekiyo, Andrea J. Sant
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00547-0