Improved production of Taxol® precursors in S. cerevisiae using combinatorial in silico design and metabolic engineering

Abstract Background Integrated metabolic engineering approaches that combine system and synthetic biology tools enable the efficient design of microbial cell factories for synthesizing high-value products. In this study, we utilized in silico design algorithms on the yeast genome-scale model to pred...

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Bibliographic Details
Main Authors: Koray Malcı, Rodrigo Santibáñez, Nestor Jonguitud-Borrego, Jorge H. Santoyo-Garcia, Eduard J. Kerkhoven, Leonardo Rios-Solis
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Microbial Cell Factories
Subjects:
Online Access:https://doi.org/10.1186/s12934-023-02251-7