Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PAR1) in vivo

Abstract Human periodontal ligament stem cells (PDLSCs) have been studied as a promising strategy in regenerative approaches. The protease-activated receptor 1 (PAR1) plays a key role in osteogenesis and has been shown to induce osteogenesis and increase bone formation in PDLSCs. However, little is...

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Bibliographic Details
Main Authors: Tomaz Alves, Letícia M. Gasparoni, Danilo Balzarini, Emmanuel Albuquerque-Souza, Victhor de Oliveira, Emanuel S. Rovai, Jose da Silva, Aldrin Huamán-Mendoza, Luiz H. Catalani, Carla R. Sipert, Marinella Holzhausen
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19520-x