Structural Basis of Ca<sup>2+</sup>-Dependent Self-Processing Activity of Repeat-in-Toxin Proteins

Structural Basis of Ca<sup>2+</sup>-Dependent Self-Processing Activity of Repeat-in-Toxin Proteins

ABSTRACT The posttranslational Ca2+-dependent “clip-and-link” activity of large repeat-in-toxin (RTX) proteins starts by Ca2+-dependent structural rearrangement of a highly conserved self-processing module (SPM). Subsequently, an internal aspartate-proline (Asp-Pro) peptide bond at the N-terminal en...

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Bibliographic Details
Main Authors: Vojtech Kuban, Pavel Macek, Jozef Hritz, Katerina Nechvatalova, Katerina Nedbalcova, Martin Faldyna, Peter Sebo, Lukas Zidek, Ladislav Bumba
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
RTX toxins
cell adhesion
clip-and-link
host-pathogen interactions
nuclear magnetic resonance
Online Access:https://journals.asm.org/doi/10.1128/mBio.00226-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00226-20

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