An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) ? agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solvent usage, crystalline intermediates and...

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Bibliographic Details
Main Authors: John R. Rizzo, Tony Y. Zhang
Format: Article
Language:deu
Published: Swiss Chemical Society 2006-09-01
Series:CHIMIA
Subjects:
Asymmetric synthesis
Navaglitazar
Noninsulin dependent diabetes mellitus (niddm)
Peroxisome proliferator activated receptor (ppar) gamma agonist
Online Access:https://chimia.ch/chimia/article/view/4210

Internet

https://chimia.ch/chimia/article/view/4210

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