Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells

Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells

Summary: Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic cells and hold great promise for novel therapies. However, several studies have reported genetic variations in iPSC genomes. Here, we investigated point mutations identified by whole-genome sequencing in...

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Bibliographic Details
Main Authors: Masahito Yoshihara, Ryoko Araki, Yasuji Kasama, Misato Sunayama, Masumi Abe, Kohji Nishida, Hideya Kawaji, Yoshihide Hayashizaki, Yasuhiro Murakawa
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313505

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http://www.sciencedirect.com/science/article/pii/S2211124717313505

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