Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of α-CTxs have been demonstrated with improved potency c...

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Bibliographic Details
Main Authors: Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Marine Drugs
Subjects:
α-conotoxin
PeIA
nicotinic acetylcholine receptor
non-natural amino acid
molecular dynamics simulations
Online Access:https://www.mdpi.com/1660-3397/22/3/110

Internet

https://www.mdpi.com/1660-3397/22/3/110

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