Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of α-CTxs have been demonstrated with improved potency c...

Celý popis

Podrobná bibliografie
Hlavní autoři: Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2024-02-01
Edice:Marine Drugs
Témata:
α-conotoxin
PeIA
nicotinic acetylcholine receptor
non-natural amino acid
molecular dynamics simulations
On-line přístup:https://www.mdpi.com/1660-3397/22/3/110

Internet

https://www.mdpi.com/1660-3397/22/3/110

Podobné jednotky