Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of α-CTxs have been demonstrated with improved potency c...
Main Authors: | , , , , , , , |
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格式: | Article |
語言: | English |
出版: |
MDPI AG
2024-02-01
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叢編: | Marine Drugs |
主題: | |
在線閱讀: | https://www.mdpi.com/1660-3397/22/3/110 |