Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study

Abstract Background Migraine is a prevalent, chronic, and multifactorial neurovascular disease. Objectives Our work aimed to investigate if the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are affected in patients with chronic migraine to improve the understanding of the...

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Main Authors: Dalia M. Labib, Montaser Hegazy, Soheir Mohamed Esmat, Enas Abdel Hamid Ali, Foraysa Talaat
Format: Article
Language:English
Published: SpringerOpen 2020-08-01
Series:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Subjects:
Online Access:http://link.springer.com/article/10.1186/s41983-020-00218-8
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author Dalia M. Labib
Montaser Hegazy
Soheir Mohamed Esmat
Enas Abdel Hamid Ali
Foraysa Talaat
author_facet Dalia M. Labib
Montaser Hegazy
Soheir Mohamed Esmat
Enas Abdel Hamid Ali
Foraysa Talaat
author_sort Dalia M. Labib
collection DOAJ
description Abstract Background Migraine is a prevalent, chronic, and multifactorial neurovascular disease. Objectives Our work aimed to investigate if the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are affected in patients with chronic migraine to improve the understanding of the etiology and pathophysiology of migraine. Subjects and methods A case-control study conducted on 30 patients with chronic migraine and 30 aged and sex-matched healthy controls. Subjects underwent full neurological and ophthalmological history, ophthalmological examination, and measuring RNFL and GCL thickness using the spectral domain-optical coherence tomography (SD-OCT). Results RNFL thinning (average, superior, inferior, nasal, and temporal) was significantly more in patients with chronic migraine than healthy control (P = 0.001, 0.022, 0.045, 0.034, and 0.001, respectively). No statistically significant difference was found between chronic migraine patients and healthy controls regarding GCL thickness (average, superior, and inferior) (P value ˃ 0.05). The average RNFL thickness was significantly thinner in migraine with aura (MwA) than migraine without aura (MwoA) (P = 0.006). The average GCL thickness was thinner in MwA than MwoA (P = 0.039). No statistically significant difference was found between the eyes on the side of the headache and the eyes of the contralateral side regarding RNFL and GCL thickness (P value ˃ 0.05). Age at onset, disease duration, headache frequency, and headache intensity showed an insignificant correlation with OCT parameters. Conclusion Retinal changes could be an association with chronic migraine that may be used as a biomarker.
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spelling doaj.art-fdce3c8fe72c46b2a8511c3ce1ec3ae12022-12-22T02:24:24ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292020-08-015611610.1186/s41983-020-00218-8Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control studyDalia M. Labib0Montaser Hegazy1Soheir Mohamed Esmat2Enas Abdel Hamid Ali3Foraysa Talaat4Neurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityOphthalmology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Nasser Institute HospitalNeurology Department, Faculty of Medicine, Cairo UniversityAbstract Background Migraine is a prevalent, chronic, and multifactorial neurovascular disease. Objectives Our work aimed to investigate if the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are affected in patients with chronic migraine to improve the understanding of the etiology and pathophysiology of migraine. Subjects and methods A case-control study conducted on 30 patients with chronic migraine and 30 aged and sex-matched healthy controls. Subjects underwent full neurological and ophthalmological history, ophthalmological examination, and measuring RNFL and GCL thickness using the spectral domain-optical coherence tomography (SD-OCT). Results RNFL thinning (average, superior, inferior, nasal, and temporal) was significantly more in patients with chronic migraine than healthy control (P = 0.001, 0.022, 0.045, 0.034, and 0.001, respectively). No statistically significant difference was found between chronic migraine patients and healthy controls regarding GCL thickness (average, superior, and inferior) (P value ˃ 0.05). The average RNFL thickness was significantly thinner in migraine with aura (MwA) than migraine without aura (MwoA) (P = 0.006). The average GCL thickness was thinner in MwA than MwoA (P = 0.039). No statistically significant difference was found between the eyes on the side of the headache and the eyes of the contralateral side regarding RNFL and GCL thickness (P value ˃ 0.05). Age at onset, disease duration, headache frequency, and headache intensity showed an insignificant correlation with OCT parameters. Conclusion Retinal changes could be an association with chronic migraine that may be used as a biomarker.http://link.springer.com/article/10.1186/s41983-020-00218-8Chronic migraineOptical coherence tomographyGanglion cell complexRetinal nerve fiber layer
spellingShingle Dalia M. Labib
Montaser Hegazy
Soheir Mohamed Esmat
Enas Abdel Hamid Ali
Foraysa Talaat
Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Chronic migraine
Optical coherence tomography
Ganglion cell complex
Retinal nerve fiber layer
title Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
title_full Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
title_fullStr Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
title_full_unstemmed Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
title_short Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study
title_sort retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine a case control study
topic Chronic migraine
Optical coherence tomography
Ganglion cell complex
Retinal nerve fiber layer
url http://link.springer.com/article/10.1186/s41983-020-00218-8
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