Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver steatosis following treatment. Here, we used small int...

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Bibliographic Details
Main Authors: Samnang Tep, Radu Mihaila, Alexander Freeman, Victoria Pickering, Felicia Huynh, Marija Tadin-Strapps, Allison Stracks, Brian Hubbard, Jeremy Caldwell, W. Michael Flanagan, Nelly A. Kuklin, Brandon Ason
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Journal of Lipid Research
Subjects:
RNAi
combination therapies
low density lipoprotein cholesterol
dyslipidemia
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520392166

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http://www.sciencedirect.com/science/article/pii/S0022227520392166

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