Combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR to Monitor In Vitro Vitetrifolin D Phase I and II Metabolism

Combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR to Monitor In Vitro Vitetrifolin D Phase I and II Metabolism

By combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR, the in vitro metabolism of vitetrifolin D, a pharmacologically active key molecule from <i>Vitex agnus-castus</i> in liver cell fractions, was investigated. Twenty-seven phase I and phase II metabolites were tentatively identified from the...

Full description

Bibliographic Details
Main Authors: Sonja Sturm, Christina Högner, Christoph Seger, Hermann Stuppner
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Metabolites
Subjects:
metabolism
liver microsomes
structure elucidation
HPLC-DAD-QTOF-MS
HPLC-SPE-NMR
HR-mass spectrometry
Online Access:https://www.mdpi.com/2218-1989/11/8/529

Internet

https://www.mdpi.com/2218-1989/11/8/529

Similar Items