Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions
Controlled polypeptide synthesis via α-amino acid N-carboxylic anhydride (NCA) polymerization using conventional primary amine initiators encounters two major obstacles: (i) normal amine mechanism (NAM) and activated monomer mechanism (AMM) coexist due to amine basicity and nucleophilicity and (ii)...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
American Association for the Advancement of Science (AAAS)
2021-01-01
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Series: | Research |
Online Access: | http://dx.doi.org/10.34133/2021/9826046 |