Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions

Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions

Controlled polypeptide synthesis via α-amino acid N-carboxylic anhydride (NCA) polymerization using conventional primary amine initiators encounters two major obstacles: (i) normal amine mechanism (NAM) and activated monomer mechanism (AMM) coexist due to amine basicity and nucleophilicity and (ii)...

Full description

Bibliographic Details
Main Authors: Lei Li, Jie Cen, Wenhao Pan, Yuben Zhang, Xuanxi Leng, Zhengqi Tan, Hao Yin, Shiyong Liu
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021-01-01
Series:Research
Online Access:http://dx.doi.org/10.34133/2021/9826046

Similar Items

Similar Items