Vildagliptin Reduces Stenosis of Injured Carotid Artery in Diabetic Mouse Through Inhibiting Vascular Smooth Muscle Cell Proliferation via ER Stress/NF-κB Pathway

Vildagliptin Reduces Stenosis of Injured Carotid Artery in Diabetic Mouse Through Inhibiting Vascular Smooth Muscle Cell Proliferation via ER Stress/NF-κB Pathway

Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel anti-hyperglycemic drugs for type 2 diabetes. It has been reported that DDP-4 inhibitor could exert pleiotropic effects on cardiovascular system. This study was to explore the effect and mechanism of vildagliptin on the stenosis of injured carotid...

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Bibliographic Details
Main Authors: Yuqin Ji, Yingbin Ge, Xinyu Xu, Sen Ye, Yuansheng Fan, Jing Zhang, Lianlian Mei, Xiaofeng Zhang, Lianghong Ying, Tao Yang, Chunjian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
vildagliptin
VSMCs proliferation
phospho-IRE-1
phospho-p65
phospho-IKKα/β
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00142/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00142/full

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