Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

Human tumors exhibit plasticity and evolving capacity over time. It is difficult to study the mechanisms of how tumors change over time in human patients, in particular during the early stages when a few oncogenic cells are barely detectable. Here, we used a Drosophila tumor model caused by loss of...

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Bibliographic Details
Main Authors: Tiantian Ji, Lina Zhang, Mingxi Deng, Shengshuo Huang, Ying Wang, Tri Thanh Pham, Andrew Alan Smith, Varun Sridhar, Clemens Cabernard, Jiguang Wang, Yan Yan
Format: Article
Language:English
Published: The Company of Biologists 2019-08-01
Series:Disease Models & Mechanisms
Subjects:
Cell polarity
Drosophila tumor model
JNK
ERK
Online Access:http://dmm.biologists.org/content/12/8/dmm040147

Internet

http://dmm.biologists.org/content/12/8/dmm040147

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