Glycovaccine Design: Optimization of Model and Antitubercular Carrier Glycosylation via Disuccinimidyl Homobifunctional Linker

Glycovaccine Design: Optimization of Model and Antitubercular Carrier Glycosylation via Disuccinimidyl Homobifunctional Linker

Conjugation via disuccinimidyl homobifunctional linkers is reported in the literature as a convenient approach for the synthesis of glycoconjugate vaccines. However, the high tendency for hydrolysis of disuccinimidyl linkers hampers their extensive purification, which unavoidably results in side-rea...

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Bibliographic Details
Main Authors: Sara Tengattini, Davide Rubes, Massimo Serra, Luciano Piubelli, Loredano Pollegioni, Enrica Calleri, Teodora Bavaro, Gabriella Massolini, Marco Terreni, Caterina Temporini
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
glycoconjugate vaccines
antitubercular vaccines
Ag85B antigen
chemical glycosylation
disuccinimidyl linkers
glycoconjugate characterization
Online Access:https://www.mdpi.com/1999-4923/15/5/1321

Internet

https://www.mdpi.com/1999-4923/15/5/1321

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