Crenigacestat (LY3039478) inhibits osteogenic differentiation of human valve interstitial cells from patients with aortic valve calcification in vitro

Crenigacestat (LY3039478) inhibits osteogenic differentiation of human valve interstitial cells from patients with aortic valve calcification in vitro

Calcific aortic valve disease (CAVD) is one of the dangerous forms of vascular calcification. CAVD leads to calcification of the aortic valve and disturbance of blood flow. Despite high mortality, there is no targeted therapy against CAVD or vascular calcification. Osteogenic differentiation of valv...

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Bibliographic Details
Main Authors: Arseniy A. Lobov, Nadezhda V. Boyarskaya, Olga S. Kachanova, Ekaterina S. Gromova, Anastassia A. Shishkova, Bozhana R. Zainullina, Alexander S. Pishchugin, Alexey A. Filippov, Vladimir E. Uspensky, Anna B. Malashicheva
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
crenigacestat
LY3039478
calcific aortic valve disease
vascular calcification
valve interstitial cells
osteogenic differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.969096/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.969096/full

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