Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini.

Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini.

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor for cholangiocarcinoma (CCA) in the Mekong Basin countries of Thailand, Lao PDR, Vietnam, Myanmar and Cambodia. Using a novel model of CCA, involving infection with gene-edited liver flukes in the hamster d...

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Bibliographic Details
Main Authors: Sujittra Chaiyadet, Sirikachorn Tangkawattana, Michael J Smout, Wannaporn Ittiprasert, Victoria H Mann, Raksawan Deenonpoe, Patpicha Arunsan, Alex Loukas, Paul J Brindley, Thewarach Laha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010839

Internet

https://doi.org/10.1371/journal.ppat.1010839

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