Modulating NMDA receptors to treat MK-801-induced schizophrenic cognition deficit: effects of clozapine combining with PQQ treatment and possible mechanisms of action

Abstract Background Clozapine has remarkable efficacy on both negative and cognitive symptoms of schizophrenia due to its slight activation of NMDA receptor. In fact, much evidence to the contrary. NMDAR is a complex containing specific binding sites, which are regulated to improve negative symptoms...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Xingqin Zhou, Gangming Cai, Shishi Mao, Dong Xu, Xijie Xu, Rongjun Zhang, Zhiwen Yao
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: BMC 2020-03-01
Цуврал:BMC Psychiatry
Нөхцлүүд:
Онлайн хандалт:http://link.springer.com/article/10.1186/s12888-020-02509-z