SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway

SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway

Abstract Recently, evidence has suggested a regulatory role for SND1 in osteoarthritis progression. Interestingly, we found that SND1 protein expression was increased, mitochondria were shrunken and decreased in number, mitochondrial membrane potential was decreased, mitochondrial ROS production was...

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Bibliographic Details
Main Authors: Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Ye
Format: Article
Language:English
Published: BMC 2023-09-01
Series:European Journal of Medical Research
Subjects:
Osteoarthritis
SND1
Mitochondrial
Extracellular matrix
The PINK1
BECN1 pathway
Online Access:https://doi.org/10.1186/s40001-023-01340-y

Internet

https://doi.org/10.1186/s40001-023-01340-y

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